Effective bone metabolism invigorating drugs

The researchers in Chemistry department, Kim Il Sung University developed Risedronate Capsules and Zoledronic Acid Injections which are world-famous for being specially effective in the treatment of bone metabolic diseases such as osteoporosis, aseptic necrosis of femur head and osteoarthritis, bone metastasis from malignant tumors including breast cancer and hypercalcemia due to malignant tumors.

Zoledronic Acid especially is one of the most powerful drugs among bone absorption inhibitors which have ever been developed and utilized in the clinical practice all over the world. This injection is an excellent medicine for the treatment of aseptic necrosis of femur head, bone metastasis from malignant tumors including breast cancer and hypercalcemia due to malignant tumors.

Zoledronic Acid and Risedronate were synthesized by our own methods based on our technology and materials. The chemical structure and purity of these substances were confirmed by modern analytical instruments such as UPLC-MS, ¹H-NMR, ¹³C-NMR, XRD and FT-IR.

The safety in use is guaranteed by the animal experiments in connection with authorized research team of the Pharmaceutical Institute, the Academy of Medical Science. The experiments were made to test acute toxicity, subacute toxicity and main action of Zoledronic Acid and Risedronate.

Risedronate Capsules and Zloedronic Acid Injections have undergone clinical trials with the aid of famous medical professors and Doctors including qualified medical staffs of Pyongyang Medical College Hospital of Kim Il Sung University, Pyongyang People's Hospital No 2, Breast Cancer Institute of Pyongyang Maternity Hospital so as to establish our own therapeutical method suitable for a constitutional peculiarity of Koreans.

Animal experiments and clinical trials have proved that Risedronate and Zoledronic Acid can treat the bone metabolic diseases caused by disorder of bone nutrition and decline of function by activating an osteoblast, inhibiting an osteoclast and adjusting abnormal calcium metabolism into a normal state. They can also treat the hypercalcemia due to tumoural skeletal metastasis by controlling a calcium level in blood vessel in a short time, and these drugs have a strong inhibitive activity of a blood vessel calcium deposit, one of the major aetiological factors in angiosclerotica.

Risedronate Capsules, registered as National Patent, have been produced since 2006, and Zoledronic Acid Injection, registered as National Science Technology Success, has been produced since 2012 in a production center of Chemistry Faculty, Kim Il Sung University. During the days, they were exhibited 18 times in International Trade Fairs and received an international recognition, and have enjoyed good reputation from the users in our country.

Our research team will develop and produce world-class drugs by simulating and interpreting Quantitative Structure-Activity Relationships on the basis of molecular design and synthetic design of new drugs with more powerful activity and less side effect.

With the aim of breaking through the cutting edge technology and ensuring quality-first, we will further develop the joint research and scholarship exchange in the fields of fine organic synthesis technology and pharmaceutical development throughout the world.